| 公告主旨 |
[演講] 10/12 詹智強 老師 主講：Sphingolipid Network Dynamics in the Nervous System: From Genetic Profiling to Pathological Mechanisms |
| 公告內容 |
臺大基蛋所Medical Genetics & Genomics Monthly Seminar演講邀請
[講題]：Sphingolipid Network Dynamics in the Nervous System: From Genetic Profiling to Pathological Mechanisms
[講者]：詹智強（臺大醫學院生理所教授）
CV：https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=12238
[時間]：2026/10/12 （星期一） 上午11：20-12：10
[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex: https://ntumc.webex.com/ntumc-tc/j.php?MTID=m9c3fb67b75982863085979dc631e414b
[摘要]：
Sphingolipids are essential structural lipids and potent signaling molecules whose metabolic dysregulation is increasingly implicated in neurodegenerative pathogenesis. However, resolving how localized sphingolipid flux drives neuronal vulnerability has been constrained by a lack of cell-type-specific, spatially resolved tools.
To address this challenge, we systematically profiled the genetic expression landscape of the sphingolipid metabolic network across the nervous system, mapping critical enzymatic nodes and regulatory checkpoints. Coupling these transcriptional profiles with targeted genetic perturbations, we altered specific metabolic branches to assess their downstream impact on neuronal homeostasis. To track these shifts in real time, we developed and deployed genetically encoded biosensors capable of monitoring subcellular sphingolipid dynamics in situ within intact tissues.
Applying this integrated platform to neurodegenerative disease models reveals that aberrant sphingolipid accumulation triggers profound lysosomal stress, characterized by impaired autophagic flux, membrane instability, and compromised clearance capacity that ultimately drives neurotoxicity. Together, our findings delineate the spatial and genetic architecture of neuronal sphingolipid homeostasis, establishing that precise control of localized sphingolipid flux is essential for preserving lysosomal fidelity and revealing new therapeutic entry points for neurodegenerative disorders.
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