| 公告主旨 |
[演講] 5/11 陳儀莊 所長 主講：Imaging and Multiomics Reveal Early Network and Metabolic Dysfunction in Preclinical Models of Alzheimer’s Disease |
| 公告內容 |
臺大基蛋所Medical Genetics & Genomics Monthly Seminar演講邀請
[講題]：Imaging and Multiomics Reveal Early Network and Metabolic Dysfunction in Preclinical Models of Alzheimers Disease
[講者]：陳儀莊 所長（中研院生物醫學研究所）
CV:https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11673
[時間]：2026/5/11 （星期一） 上午11：20-12：10
[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:
https://ntumc.webex.com/ntumc-tc/j.php?MTID=m8ad5a9f0d3e4bd0dbfc68d56f560fffc
[摘要]：
Alzheimers disease remains a major unmet medical need, with few effective disease-modifying therapies. To identify early mechanisms and therapeutic opportunities, we use preclinical models of Alzheimers disease and an integrative approach that combines brain imaging with multiomic analyses. Using diffusion tensor imaging （DTI）, we detect early disruption of hippocampal-prefrontal connectivity before overt disease onset. Multiomic analyses further reveal coordinated changes in lipid metabolism and glial support pathways, pointing to impaired network maintenance as a key feature of disease progression. We focus on adenosine signaling as a central regulator. Pharmacological inhibition of ENT1 restores metabolic homeostasis, improves network connectivity, and reduces pathological changes. Together, these findings support a model in which energy imbalance drives neurodegeneration across multiple cell types and highlight new opportunities for disease-modifying intervention.
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