| 公告主旨 |
[演講] 2/9 李士傑 老師 主講：From Embryos to Pathology: Zebrafish Illuminating the Origins of Human Disease |
| 公告內容 |
臺大基蛋所Medical Genetics & Genomics Monthly Seminar演講邀請
[講題]：From Embryos to Pathology: Zebrafish Illuminating the Origins of Human Disease
[講者]：李士傑 教授（臺大生科系）
CV:https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11312
[時間]：2026/2/9 （星期一） 上午11：20-12：10
[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:
https://ntumc.webex.com/ntumc-tc/j.php?MTID=mb15539d23472f963e132dba3e656e465
[摘要]：
The zebrafish （Danio rerio） has become an increasingly important vertebrate model for investigating the developmental origins and mechanisms of human diseases. Many congenital and early-onset disorders arise from disruptions in embryonic processes such as cell fate specification, tissue morphogenesis, and organ maturation. The zebrafish offers a unique opportunity to directly observe these processes in a living organism, as its embryos develop externally, rapidly, and with optical transparency, allowing real-time visualization of disease-relevant cellular and physiological defects.
Genetically, zebrafish exhibit strong conservation with humans, with most disease-associated pathways and a majority of human genes represented in the zebrafish genome. Modern genome-editing approaches, particularly CRISPR/Cas9, enable efficient generation of loss- and gain-of-function models that recapitulate key features of human diseases. Zebrafish models have been widely applied to study neurodevelopmental disorders, cardiovascular and metabolic diseases, cancer, and rare genetic syndromes, often revealing early pathogenic events that are difficult to capture in mammalian systems.
Beyond genetic diseases, zebrafish are highly suited for functional screening of disease modifiers and therapeutic compounds. Their small size and high reproductive capacity support in vivo drug screening and toxicity testing at scales not feasible in rodents. Importantly, disease phenotypes can be assessed at molecular, cellular, and whole-organism levels within a matter of days.
By integrating embryonic biology with disease modeling, zebrafish provide a powerful platform for identifying pathogenic mechanisms, biomarkers, and therapeutic targets. This model system thus plays a critical role in bridging basic developmental research with translational and precision medicine efforts.
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